Hot sale top quality of Tacrolimus 109581-93-3 with fast delivery CAS NO.109581-93-3

Hot sale top quality of  Tacrolimus 109581-93-3 with fast delivery

Tacrolimusmonohydrate(FK506monohydrate;Fujimycinmonohydrate;FR900506monohydrate)inhibitscalcium-dependentevents,suchasIL2genetranscription,NOsynthaseactivation,celldegranulation,andapoptosis.TacrolimusalsopotentiatestheactionsofglucocorticoidsandprogesteronebybindingtoFKBPscontainedwithinthehormonereceptorcomplex,preventingdegradation.TheagentmayenhanceexpressionoftheTGFβ-1geneinafashionanalogoustothatdemonstratedforCsA.TcellproliferationinresponsetoligationoftheTcellreceptorisinhibitedbyTacrolimus.TreatmentwithalowconcentrationofTacrolimus(FK506,10μg/L)doesnotsignificantlyaffecttheproliferationofMH3924Acells(P=0.135).UpontreatmentwithhigherconcentrationsofTacrolimus(1001,000μg/L),theproliferationofMH3924Acellsissignificantlyenhanced(P0.05).However,whendifferentconcentrationsofAMD3100arecombinedwith100μg/LTacrolimus,theinvitroproliferationofMH3924Acellsisincreased(P<0.01).

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