Global trader offer Tacrolimus 109581-93-3 with low price CAS NO.109581-93-3

Global trader offer Tacrolimus 109581-93-3  with low price

At the molecular level, the role of tacrolimus is obviously to combine with cellular protein (FKBP12) and accumulate in cells to produce effects. The FKBP12-tacrolimus complex specifically binds to and inhibits calcinurin, which inhibits the calcium ion-dependent signaling pathway produced in T cells, thereby preventing the transcription of discontinuous lymphokine genes. This drug is a highly immunosuppressive drug, and its activity has been confirmed in in vitro and in vivo experiments. This drug inhibits the formation of cytotoxic lymphocytes, which is the main role of transplant rejection. This drug inhibits the activation of T cells and the proliferation of T helper cells dependent on B cells. It also inhibits the production of lymphokines such as interleukin-2, interleukin-3 and gamma-interferon and the expression of interleukin-2 receptors. At the molecular level, the drug’s effect seems to be produced by binding to cellular protein (FKBP), which also causes the compound to accumulate in cells. In in vivo experiments, it was found that the drug has been shown to be effective for liver and kidney transplantation.

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